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Efficient Synthesis of Spironaphthopyrano[2,3-d]pyrimidine-5,3’-indolines under Solvent-free Conditions Catalyzed by SBA-Pr-SO3H as a Nanoporous Acid Catalyst

Ghodsi Mohammadi Ziarani, Negar Lashgari, Sakineh Faramarzi, Alireza Badiei


A green, simple one-pot synthesis of spironaphthopyrano[2,3-d]pyrimidine-5,3'-indoline derivatives by a three-component reaction of isatins, 2-naphthol, and barbituric acids under solvent-free conditions in the presence of SBA-Pr-SO3H has been accomplished. Sulfonic acid functionalized SBA-15 (SBA-Pr-SO3H) as a heterogeneous nanoporous solid acid catalyst was found to be an efficient and recyclable acid catalyst in this synthesis.


Spironaphthopyrano[2,3-d]pyrimidine-5,3'-indoline; Isatin; Barbituric acid; Functionalized SBA-15; Green synthesis

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