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Catalytic Activity of Ruthenium(III) on the Oxidation of an Anticholinergic Drug-Atropine Sulfate Monohydrate by Copper(III) Periodate Complex in Aqueous Alkaline...

Kirthi S. Byadagi, Sharanappa T. Nandibewoor, Shivamurti A. Chimatadar

Abstract


Atropine sulfate monohydrate (ASM) is an anticholinergic drug, having a wide spectrum of activity. Hence, the kinetics of oxidation of ASM by diperiodatocuperate (DPC) in the presence of micro (10–6) amounts of Ru(III) catalyst has been investigated spectrophotometrically in aqueous alkaline medium at I = 0.50 mol dm–3. The reaction between DPC and ASM exhibits 1:2 stoichiometry (ASM:DPC) i. e., one mole of ASM require two moles of DPC to give products. The main oxidation products were confirmed by spectral studies. The reaction is first order with respect to [DPC] and [Ru(III)], while the order with respect to [ASM] and [OH–] was less than unity. The rates decreased with increase in periodate concentration. The reaction rates revealed that Ru(III) catalyzed reaction was about seven-fold faster than the uncatalyzed reaction. The catalytic constant (KC) was also determined at different temperatures. A plausible mechanism is proposed. The activation parameters with respect to slow step of the mechanism were calculated and the thermodynamic quantities were also determined. Kinetic experiments suggest that [Cu(H2IO6)(H2O)2] is the reactive Cu(III) species and [Ru(H2O)5OH]2+ is the reactive Ru(III) species.


Keywords


Atropine sulfate, Diperiodatocuprate(III), Oxidation, Ru(III) Catalysis, Kinetics, Active species

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Copyright (c) 2013 Kirthi S. Byadagi, Sharanappa T. Nandibewoor, Shivamurti A. Chimatadar

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