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Syntheses, Characterization and Crystal Structures of Dicyanamide Bridged Polynuclear Copper(II) and Zinc(II) Complexes with Urease Inhibitory Activity

Li Zhang, Yuqing Gu, Xinhui Feng, Ting Yang, Xiaoyan Li, Jing Wang, Zhonglu You


A pair of structurally similar dicyanamide bridged copper(II) and zinc(II) complexes [CuL(dca)]n (1) and [ZnL(dca)]n (2), were prepared from the fluorine containing Schiff base 5-fluoro-2-(((2-hydroxyethyl)imino)methyl)phenol (HL). The compounds were characterized by physico-chemical methods. Structures of the complexes were confirmed by single crystal X-ray diffraction. The Cu atom in complex 1 is in square pyramidal coordination, whereas the Zn atom in complex 2 is in trigonal bipyramidal coordination. The copper complex has effective Jack bean urease inhibitory activity, with IC50 value of 0.14±0.12 μmol L–1.




Schiff base; copper and zinc complexes; crystal structure; urease inhibition

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Copyright (c) 2020 Baihui He, Jiahui Wu, Ting Yang, Xiaoyan Li, Jing Wang, Zhonglu You

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