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Syntheses, Characterization and Crystal Structures of Dicyanamide Bridged Polynuclear Copper(II) and Zinc(II) Complexes with Urease Inhibitory Activity

Li Zhang, Yuqing Gu, Xinhui Feng, Ting Yang, Xiaoyan Li, Jing Wang, Zhonglu You

Abstract


A pair of structurally similar dicyanamide bridged copper(II) and zinc(II) complexes [CuL(dca)]n (1) and [ZnL(dca)]n (2), were prepared from the fluorine containing Schiff base 5-fluoro-2-(((2-hydroxyethyl)imino)methyl)phenol (HL). The compounds were characterized by physico-chemical methods. Structures of the complexes were confirmed by single crystal X-ray diffraction. The Cu atom in complex 1 is in square pyramidal coordination, whereas the Zn atom in complex 2 is in trigonal bipyramidal coordination. The copper complex has effective Jack bean urease inhibitory activity, with IC50 value of 0.14±0.12 μmol L–1.

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Keywords


Schiff base; copper and zinc complexes; crystal structure; urease inhibition

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DOI: http://dx.doi.org/10.17344/acsi.2022.7578

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Copyright (c) 2020 Baihui He, Jiahui Wu, Ting Yang, Xiaoyan Li, Jing Wang, Zhonglu You

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