Cover Image

Synthesis, Crystal Structures and Urease Inhibition of Mononuclear Copper(II) and Nickel(II) Complexes with Schiff Base Ligands

Jian Jiang, Peng Liang, Huiyuan Yu, Zhonglu You


Three mononuclear copper(II) and nickel(II) complexes, [Cu(L1)(NCS)(CH3OH)] (1), [Cu(L2)(NCS)] (2) and [Ni(L2)(N3)] (3), where L1 and L2 are the monoanionic forms of the Schiff bases N'-(pyridin-2-ylmethylene)picolinohydrazide (HL1) and 4-methyl-2-(((pyridin-2-ylmethyl)imino)methyl)phenol (HL2), have been prepared and characterized by elemental analysis, IR and UV-Vis spectroscopy, as well as single crystal X-ray diffraction studies. The Cu atom in complex 1 is in a square pyramidal coordination, with the three N atoms of the ligand L and the N atom of the thiocyanate ligand in the basal plane, and with the methanol O atom at the apical position. The Cu and Ni atoms in complexes 2 and 3 are in square planar coordination, with the three donor atoms of the Schiff base ligands and the terminal N atoms of thiocyanate and azide ligands. Complexes 1 and 2 inhibit the Jack bean urease with IC50 value of 0.33±0.12 and 0.39±0.10 μmol L–1, respectively. Molecular docking study was performed to investigate the interaction between the complexes and the enzyme.


Schiff base; Copper complex; Nickel complex; Crystal structure; Urease inhibition



  • There are currently no refbacks.

Copyright (c) 2020 Jian Jiang, Peng Liang, Huiyuan Yu, Zhonglu You

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.