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A Novel Method for the One-pot Five-component Synthesis Highly Functionalized Pyranopyrazoles Catalyzed by CuI Nanoparticles

Javad Safaei-Ghomi, Abolfazl Ziarati, Mehrnoush Tamimi

Abstract


A novel one-pot, five-component reaction for the synthesis of highly functionalized pyranopyrazoles from acid chlorides, Meldrum's acid, hydrazine hydrate, aromatic aldehydes and malononitrile in the presence of catalytic amount of CuI nanoparticles in aqueous media is reported. This method provides several benefits such as in situ preparation of beta-ketoester, mild reaction conditions, and environmentally friendly, waste-free and simple work-up procedure with excellent yields. The catalyst could be recovered and reused for several times with almost consistent catalytic activity.

 


Keywords


Pyranopyrazoles, one pot, five-component reaction, in situ preparation, CuI nanoparticles.

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