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(E)-1-(4-Hydroxyphenyl)-3-(substituted-phenyl)prop-2-en-1-ones: Synthesis, In Vitro Cytotoxic Activity and Molecular Docking Studies

Lütfiye Sirka, Hacer Doğan, Mehmet Refik Bahar, Eray Çalışkan, Suat Tekin, Harun Uslu, Kenan Koran, Süleyman Sandal, Ahmet Orhan Görgülü

Abstract


A series of chalcone compounds (211) were designed and synthesized to determine their cytotoxic effects. The structures of 211 were fully characterized by their physical and spectral data. The in vitro cytotoxic effects of 211 were evaluated against human ovarian cancer (A2780), breast cancer (MCF-7) and prostate cancer (PC-3 and LNCaP) cell lines. The activity potentials of compounds were further evaluated through molecular docking studies with AutoDock4 and Vina softwares. All the compounds (except compound 5) showed significant cytotoxic effects at high doses in all cancer cell lines. Among all the compounds studied, one compound i.e. compound 2 demonstrated dose-dependent activity, particularly against A2780/LNCaP cancer cell lines. The most effective compounds 8, 9, 10 and 11 reduced the cell viability of A2780, MCF-7, PC-3 and LNCaP cells by 50–98%, while other compounds 2, 4 and 7 reduced the cell viability of A2780 cells by 70–90% at concentrations of 50 and 100 µM.


Keywords


Chalcone; Cytotoxic; A2780; MTT assay; Molecular docking

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DOI: http://dx.doi.org/10.17344/acsi.2021.7080

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Copyright (c) 2020 Lütfiye Sirka, Hacer Doğan, Mehmet Refik Bahar, Eray Çalışkan, Suat Tekin, Harun Uslu, Kenan Koran, Süleyman Sandal, Ahmet Orhan Görgülü

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