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Novel Structural Hybrids of Pyrrole and Thiazole Moieties: Synthesis and Evaluation of Antibacterial and Antifungal Activities

Mohamed Salem, Samir Abbas, Marwa El-Sharief, Mohamed Helal, Moustafa Gouda, Mohammed Assiri, Mohammed Assiri, Tarik Ali, Tarik Ali

Abstract


One of the best ways to design new biocidal agents is synthesizing hybrid molecules by combining two or more bioactive moieties in a single molecular scaffold. So, new series of pyrroles bearing a thiazole moiety were synthesized using 1-methyl-1H-pyrrole-2-carbaldehyde thiosemicarbazones 1ac. Cyclization of thiosemicarbazone derivatives 1ac with ethyl chloroacetate, ethyl 2-chloropropanoate, chloroacetone and phenacyl bromide afforded the corresponding thiazolidin-4-ones 2ac, 5-methylthiazolidin-4-ones 3ac, 4-methyl-2,3-dihydrothiazoles 4ac, and 4-phenyl-2,3-dihydrothiazoles 5ac, respectively. The antimicrobial activity of the new thiazole derivatives was evaluated.


Keywords


Pyrroles; Thiosemicarbazones; Thiazoles; Antibacterial and antifungal activities

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DOI: http://dx.doi.org/10.17344/acsi.2021.6980

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Copyright (c) 2020 Mohamed Salem, Samir Abbas, Marwa El-Sharief, Mohamed Helal, Moustafa Gouda

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