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Synthesis, Crystal Structures and Urease Inhibition of 4-Bromo-N'-(1-(pyridin-2-yl)ethylidene)benzohydrazide and Its Dinuclear Copper(II) Complex

Hui Zhao, Xiu-Rui Liu, Xue Wang, Jing Hu, Ya-Jun Cai, Qi-An Peng

Abstract


A new dinuclear copper(II) complex [Cu2(μ-Br)2L2]·0.5MeOH with the benzohydrazone ligand 4-bromo-N'-(1-(pyridin-2-yl)ethylidene)benzohydrazide (HL) has been synthesized and characterized by elemental analysis, IR and UV-Vis spectroscopic studies. Single crystal structures of the complex and the benzohydrazone compound were studied. The Cu atoms in the complex are coordinated by two benzohydrazone ligands and two Br bridging groups, forming square pyramidal coordination. The complex has good inhibitory activity on Jack bean urease, with IC50 value of 1.38 μmol·L-1.


Keywords


Benzohydrazone; copper complex; crystal structure; biological activity

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DOI: http://dx.doi.org/10.17344/acsi.2021.6781

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Copyright (c) 2020 Hui Zhao, Xiu-Rui Liu, Xue Wang, Jing Hu, Ya-Jun Cai, Qi-An Peng

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