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Chitosan-silica Sulfate Nano Hybrid: An Efficient Biopolymer Based-heterogeneous Nano Catalyst for Solvent-free Synthesis of 3,4-Dihydropyrimidine-2(1H)-one/thiones

Somayeh Behrouz, Masoome Nazar Abi, Mohammad Amin Piltan


A green and highly efficient approach for the synthesis of 3,4-dihydropyrimidine-2(1H)-one/thione derivatives is described. In this approach, the three-component Biginelli reaction between (thio)urea, methyl acetoacetate and aldehydes under solvent-free condition in the presence of chitosan-silica sulfate nano hybrid (CSSNH) as a green and heterogeneous nano catalyst affords the corresponding products in good to excellent yields and in short reaction times. CSSNH is a cheap, eco-friendly, and non-toxic nano catalyst that could be easily prepared, handled, and reused for many reaction runs without significant loss of its activity.


Chitosan-silica sulfate nano hybrid; 3,4-Dihydropyrimidines; Green chemistry; Heterogeneous catalysis; Multicomponent reaction

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Copyright (c) 2020 Somayeh Behrouz, Masoome Nazar Abi, Mohammad Amin Piltan

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