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Efficient and Facile Synthesis of Chromenopyrano[2,3-b]pyridine Derivatives Catalyzed by Sodium Carbonate

Raziyeh Keshavarz, Mahnaz Farahi, Bahador Karami


In this research, a number of new and known chromenopyrano[2,3-b]pyridine derivatives have been prepared. Initially, according to the reported procedure, pyrano[2,3-c]chromene derivatives were synthesized by the reaction between 4-hydroxycoumarin, aromatic aldehydes and malononitrile using silica sodium carbonate (SSC) as the catalyst. Next, the prepared pyrano[2,3-c]chromenes were reacted by dimethyl acetylenedicarboxylate (DMAD) or cyclohexanone in the presence of sodium carbonate to produce chromenopyrano[2,3-b]pyridine derivatives. The presented protocol avoids the use of expensive catalysts and gives useful potentially bioactive heterocycles in excellent to high yields.


Chromenopyrano[2,3-b]pyridine; pyrano[2,3-c]chromene, dimethyl acetylenedicarboxylate, cyclohexanone

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Copyright (c) 2020 Raziyeh Keshavarz, Mahnaz Farahi, Bahador Karami

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