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Influence of TiO2 on Mucosal Permeation of Aceclofenac: Analysis of Crystal Strain and Dislocation Density

Souvik Nandi, Satyaki Aparajit Mishra, Rudra Narayan Sahoo, Rakesh Swain, Subrata Mallick

Abstract


Titanium dioxide can adhere with human epithelial cells and have good tolerability. Present work has been undertaken to explore the influence of TiO2 on mucosal permeation of aceclofenac. Mucosal permeation of aeclofenac solution containing TiO2 has been carried out. In fourier transform infrared spectrosopy (FTIR), the intensity of the peaks has decreased along with the increase of TiO2 content in the formulation indicating a possible binding between drug and TiO2. Melting enthalpy has been decreased with the increased content of TiO2 in the solid. The status of crystal strain and dislocation density of TiO2 and aceclofenac in the solid state formulation has also been evaluated from Xray Diffraction data using Debye-Scherrer’s equation. Mucosal permeation of aceclofenac has shown sustained effect for more than 20 h in presence of titanium dioxide. Titanium dioxide could be used in designing formulation for sustaining mucosal aceclofenac delivery after performing risk assessment study.


Keywords


Aceclofenac; titanium dioxide; mucosal permeation; crystal strain; dislocation density; in vitro diffusion

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DOI: http://dx.doi.org/10.17344/acsi.2020.6129

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Copyright (c) 2020 Souvik Nandi, Satyaki Aparajit Mishra, Rudra Narayan Sahoo, Rakesh Swain, Subrata Mallick

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