
Synthesis, Characterization and Crystal Structures of Fluoro-Substituted Aroylhydrazones with Antimicrobial Activity
Abstract
A series of five new fluoro-substituted aroylhydrazones were prepared and structurally characterized by elemental analysis, IR, UV-Vis and 1H NMR spectroscopy, as well as single crystal X-ray diffraction. The compounds were evaluated for their antibacterial (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas fluorescence) and antifungal (Candida albicans and Aspergillus niger) activities by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method. The biological assay indicated that the presence of the electron-withdrawing groups in the aroylhydrazones improved their antimicrobial activities.
Keywords
Aroylhydrazone; antimicrobial activity; synthesis; X-ray diffraction
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PDFDOI: http://dx.doi.org/10.17344/acsi.2020.6051
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Copyright (c) 2020 Fu-Ming Wang, Li-Jie Li, Guo-Wei Zang, Tong-Tong Deng, Zhong-Lu You

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