Cover Image

First Estimation of Reference Intervals for Thyroid-Stimulating Hormone and Thyroid Hormones in Slovenian Population

Adrijana Oblak, Ajda Biček, Edvard Pirnat, Katja Zaletel, Simona Gaberšček

Abstract


For thyroid function estimation and clinical decision making, use of appropriate reference intervals for thyroid-stimulating hormone (TSH), free thyroxine (fT4) and free triiodothyronine (fT3) is crucial. For each laboratory, establishment of own reference intervals is advised. For the first Slovenian estimation of reference intervals for thyroid hormones a large group of 1722 healthy individuals without thyroid disease was established retrospectively. Hormone analyses were performed on automated analyser Advia Centaur XP Immunoassay System (Siemens Healthineers), which reference intervals for TSH, fT4 and fT3 were 0.55-4.78 mIU/L, 11.5-22.7 pmol/L, and 3.5-6.5 pmol/L, respectively. Statistical analysis followed non-parametric percentile method. Our laboratory reference intervals for TSH, fT4 and fT3 are mostly narrower than intervals given by manufacturer. Median value, lower and upper limit for TSH, fT4 and fT3 were 1.98 (0.59-4.23) mIU/L, 14.5 (11.3-18.8) pmol/L and 4.82 (3.79-6.05) pmol/L, respectively. Most likely, an inclusion of a high number of healthy individuals without thyroid disease was a reason for such results.


Keywords


reference intervals; thyroid-stimulating hormone; thyroid hormones; immunoassays; interferences

Full Text:

PDF


DOI: http://dx.doi.org/10.17344/acsi.2020.5922

Refbacks

  • There are currently no refbacks.


Copyright (c) 2020 Adrijana Oblak, Ajda Biček, Edvard Pirnat, Katja Zaletel, Simona Gaberšček

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.