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Synthesis and in vitro Anticancer Activity of Novel Heterocycles Utilizing Thiophene Incorporated Thioureido Substituent as Precursors

Marwa Abdel-motaal, Asmaa L. Alanzy, Medhat Asem

Abstract


Ethyl 2-(3-allylthioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (1) was used as a building block for synthesis of new heterocycles. Pyrimidine and thiazole moieties were achieved upon condensation of compound 1 with various reagents such as chloroacetic acid, dietyl malonate, ninhydrin, 2,3-epoxy-2,3-dihydro-1,4-naphthoquinone, and hydrazine hydrate. The structures of the newly synthesized compounds were confirmed using spectral measurements. The prepared products were evaluated for their anticancer activity against colon HCT-116 human cancer cell line. Compounds 6, 9, 10a, 11, 12, 15 have displayed potent activity.

Keywords


Tetrahydrobenzo[b]thiophene; thiourea substituent; heterocycles; anticancer

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DOI: http://dx.doi.org/10.17344/acsi.2019.5571

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Copyright (c) 2020 MARWA ABDEL-MOTAAL, ASMAA L. ALANZY, MEDHAT ASEM

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