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Room Temperature Synthesis and Characterization of Novel Bi(III) Complex with 2-Amino-3-Carbomethoxy-4,5,6,7-Tetrahydrobenzo[B]Thiophene as Potential Antimicrobial Agent

Emmanuel Fondjo Sopbué, Désire André Siéwé, Jean-de-Dieu Tamokou, Steve Endeguele Ekom, Sorel Kamal Dimo Djeukoua, Giscard Doungmo, Mallory E. Walters, Appolinaire Tsopmo, Peter F. W. Simon, Jules Roger Kuiate

Abstract


A novel bismuth(III) complex with 2-amino-3-carbomethoxy-4,5,6,7-tetrahydrobenzo[b]thiophene (ACTT) as a ligand have been synthesized. The novel complex was characterized on the basis of its IR, NMR, elemental analysis and MS spectral data. It was found that the ligand behaves as a monodentate chelating agent and bonds to the metal ion through the nitrogen atom of the amino group to form the [BiIII(ACTT)6]Cl3 complex. The new complex compound displayed significant antimicrobial activity (MIC = 8–32 μg/mL) against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Shigella flexneri, Candida albicans, Candida tropicalis and Cryptococcus neoformans.

Keywords


Room temperature synthesis; antimicrobial; complexation reaction; 2-aminothiophene; bismuth

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DOI: http://dx.doi.org/10.17344/acsi.2019.5365

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Copyright (c) 2019 Emmanuel Fondjo Sopbué, Désire André Siéwé, Jean-de-Dieu Tamokou, Steve Endeguele Ekom, Sorel Kamal Dimo Djeukoua, Giscard Doungmo, Mallory E. Walters, Appolinaire Tsopmo, Peter F. W. Simon, Jules Roger Kuiate

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