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Synthesis, Spectroscopic Characterization, Crystal Structures and Antibacterial Activity of Vanadium(V) Complexes of Fluoro- and Chloro-Substituted Benzohydrazone ligands

En-Cheng Liu, Wei Li, Xiao-Shan Cheng

Abstract


A new vanadium(V) complex, [VOL(OMe)(MeOH)]·MeOH (1·MeOH), was prepared by the reaction of VO(acac)2 with 2-chloro-N'-(5-fluoro-2-hydroxybenzylidene)benzohydrazide (H2L) in methanol. By addition of salicylhydroxamic acid (HSHA) to the methanolic solution of 1, a new salicylhydroxamate-coordinated vanadium(V) complex, [VOL(SHA)]·H2O (2·H2O), was obtained. Both complexes were characterized by elemental analysis, infrared spectroscopy, thermal analysis and single crystal X-ray diffraction. Complex 1 crystallizes with methanol molecule as a solvate, and complex 2 as a monohydrate. The V atoms in the complexes are in octahedral coordination. In the crystal structure of 1·MeOH, the vanadium complexes are linked by methanol solvate molecules through intermolecular O–H∙∙∙N and O–H∙∙∙O hydrogen bonds to form chains along the c axis. In the crystal structure of 2·H2O, the vanadium complexes are linked by water molecules through intermolecular O–H∙∙∙O hydrogen bonds, to form 1D chains along the a axis. The chains are further linked through intermolecular O–H∙∙∙N and O–H∙∙∙O hydrogen bonds in the c direction to form 2D layers. The antimicrobial activities of the complexes against K. pneumoniae, S. aureus, P. aeroginosa, E. coli, and B. subtilis were investigated.


Keywords


Hydrazone ligand; Salicylhdroxamate ligand; Vanadium complex; Crystal structure; Antibacterial activity.

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DOI: http://dx.doi.org/10.17344/acsi.2019.5220

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Copyright (c) 2019 En-Cheng Liu, Wei Li, Xiao-Shan Cheng

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