Cover Image

Synthesis and Antimicrobial Evaluation of Some New Pyrazolo[1,5-a]pyrimidine and Pyrazolo[1,5-c]triazine Derivatives Containing Sulfathiazole Moiety

Elsherbiny Hamdy El-Sayed, Ahmed Ali Fadda, Ahmed Mohamed El-Saadaney


A number of important fused heterocyclic systems have been prepared by the reaction of 4-((3,5-diamino-1H-pyrazol-4-yl)-diazenyl)-N-(thiazol-2-yl)-benzenesulfonamide with some bifunctional nucleophiles such as ethyl acetoacetate, acetylacetone or arylidenemalonononitrile derivatives to obtain pyrazolo[1,5-a]pyrimidine derivatives. The structures of the newly synthesized compounds were determined based on their IR, 1H and 13C NMR and mass spectroscopic data. Most of the compounds produced showed good antibacterial and antifungal activity.


Sulfathiazole; benzenesulfonamide; pyrazole; antimicrobial evaluation

Full Text:




  • There are currently no refbacks.

Copyright (c) 2020 Elsherbiny h El-Sayed

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.