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A Novel Electrochemical CuO-Nanostructure Platform for Simultaneous Determination of 6-thioguanine and 5-fluorouracil Anticancer Drugs

Masoud Fouladgar

Abstract


Analysis of anticancer drugs is very important and necessary for the correct administration of them in the human body. Electrochemical behavior of 6-thioguanine (6-TG) has been studied using a carbon paste electrode modified by 1-ethyl-3-methylimidazolium tetrafluoroborate (ionic liquid) (1E3MIBF4) and CuO nanoparticles (CuO/1E3MIBF4/CPE). Using square wave voltammetry showed the linear relation between net anodic current and concentration of 6-TG in the range of 70 nmol L-1 to 520 mmol L-1 6-TG with the detection limit of 20 nmol L-1 6-TG. The proposed modified electrode had excellent repeatability (RSD = 1.31%, n = 5) and long term stability (2.9% deviation in 25 days). The diffusion coefficient of 6-TG on the CuO/1E3MIBF4/CPE was found to be 1.54 × 10-5 cm2s1 .The CuO/1E3MIBF4/CPE was successfully applied for the determination of 6-TG in real samples. In addition, the anodic peaks of 6-TG and fluorouracil (5-FU) in their mixture can be well separated using CuO/1E3MIBF4/CPE and simultaneous determination of them was studied.


Keywords


6-Thioguanine; 5- Fluorouracil; CuO nanoparticles; 1-ethyl-3-methylimidazolium tetrafluoroborate; voltammetry

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DOI: http://dx.doi.org/10.17344/acsi.2019.4986

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Copyright (c) 2020 Masoud Fouladgar

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