Cover Image

Synthesis, Labeling and Biological Evolution of New Thiopyrano[2,3-b]pyridine Derivatives as Potential Anticancer Agents

Mamdouh Sofan, Wafaa Hamama, Ibrahim Ibrahim EL-Hawary, Ismail Taha Ibrahim, Hanafi Hassan Zoorob

Abstract


The new thiopyrano[2,3-b]pyridines 49 could be synthesized from the nicotinonitrile derivative 1. The cytotoxicity activity of the selected compounds 5, 6 and 8 was tested against MCF-7 and HCT-116 cell lines. The compound 5 (TP5) exhibited significant inhibitory activity and displayed the most potent activity, more than 6 and 8. The compound 5 with potent inhibitory activity in tumor growth inhibition would be a potential anticancer agent. In the light of this result, the labeled 125I-compound 5 (125I-TP5) was prepared and its cytotoxicity against ascites tumor in mice has been evaluated. The results show that compound 5 (TP5) may be potentially used as a radiopharmaceutical for tumor diagnosis when labeled with 125I.


Keywords


Nicotinonitrile; thiopyrano[2,3-b]pyridine; cytototoxic activity; ascites tumor

Full Text:

PDF


DOI: http://dx.doi.org/10.17344/acsi.2019.4980

Refbacks

  • There are currently no refbacks.


Copyright (c) 2019 Mamdouh Sofan, Wafaa Hamama, Ibrahim Ibrahim EL-Hawary, Ismail Taha Ibrahim, Hanafi Hassan Zoorob

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.