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Tacrolimus as Antifungal Agent

Lyudmyla Antypenko, Fatuma Meyer, Zhanar Sadykova, Leif-Alexander Garbe, Karl G. Steffens

Abstract


Tacrolimus (FK506) is an immunosuppressant drug widely used to avoid organ rejection in transplant patients. It has a profound influence on the cellular stress response by interfering with the calmodulin-calcineurin signaling pathway. In this context FK506 also became a valuable antifungal drug in medical care. Here it is shown in vitro that tacrolimus has a potent growth inhibition activity against 11 fungi and 3 oomycetes of agricultural importance. The significance of this finding is discussed with respect to crop protection. The in silico molecular docking to 6 major antifungal enzymes determined UDP-N-acetylmuramoyl-L-alanine: D-glutamate ligase (MurD) as the main target by the best affinity score.


Keywords


Tacrolimus; Antiphytofungal activity

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DOI: http://dx.doi.org/10.17344/acsi.2018.4723

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Copyright (c) 2019 Lyudmyla Antypenko, Fatuma Meyer, Zhanar Sadykova, Leif-Alexander Garbe, Karl G. Steffens

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