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Synthesis and Characterization of Novel Five-membered Heterocycles and Their Activity Against Candida Yeasts

Hiba Maher Tawfeeq, Rasim Farraj Muslim, Obaid Hasan Abid, Mustafa Nadhim Owaid

Abstract


Some new tetrazole derivatives were prepared by the reaction between the prepared azomethine compounds I6I10 with sodium azide in anhydrous tetrahydrofuran (THF) with a few drops of distilled water and under reflux conditions. Azomethine compounds were prepared by thermal condensation reactions of aromatic aldehydes with primary aromatic amines. The prepared compounds (tetrazole derivatives) were screened for their antibacterial activity (by disc diffusion method). Compound I6 is the most active derivative that has recorded a significantly (p<0.01) stronger influence to inhibit the growth of Candida zeylanoides with an average zone of inhibition of 26.0 mm. Derivatives I7 and I9 showed the lowest zone of inhibition of 8.0 mm against Candida zeylanoides. This study may be helpful in designing more potential anticandidal agents for therapeutic use in the future.


Keywords


Candida sp.; Pharmaceutical; Azomethine; Sodium azide; Biological activity.

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DOI: http://dx.doi.org/10.17344/acsi.2018.4719

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Copyright (c) 2019 Hiba Maher Tawfeeq, Rasim Farraj Muslim, Obaid Hasan Abid, Mustafa Nadhim Owaid

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