
Study On Synthesis and Biological Activity of Some Pyridopyridazine Derivatives
Abstract
In this study, new pyrido[3,4-d]pyridazine derivatives were synthesized and evaluated for their in vitro antibacterial, antifungal and antimycobacterial activities. Among the synthesized compounds, compound 10 (1-(4-benzylpiperazin-1-yl)pyrido[3,4-d]pyridazin-4(3H)-one) and compound 12 (1-(4-benzylpiperidin-1-yl)pyrido[3,4-d]pyridazin-4(3H)-one) were found to have the highest antimycobacterial activity. However, all compounds were found ineffective against tested Gram-positive, Gram-negative bacteria and fungus.
Keywords
pyrido[3,4-d]pyridazine derivatives; pyrido[3,4-d]pyridazin-4(3H)-one; pyrido[3,4-d]pyridazin-1(2H)-one; antimycobacterial activity
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PDFDOI: http://dx.doi.org/10.17344/acsi.2018.4590
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