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Study On Synthesis and Biological Activity of Some Pyridopyridazine Derivatives

Sevilay Akçay, Mahmut Ülger, Fatma Kaynak Onurdağ, Yasemin Dündar

Abstract


In this study, new pyrido[3,4-d]pyridazine derivatives were synthesized and evaluated for their in vitro antibacterial, antifungal and antimycobacterial activities. Among the synthesized compounds, compound 10 (1-(4-benzylpiperazin-1-yl)pyrido[3,4-d]pyridazin-4(3H)-one) and compound 12 (1-(4-benzylpiperidin-1-yl)pyrido[3,4-d]pyridazin-4(3H)-one) were found to have the highest antimycobacterial activity. However, all compounds were found ineffective against tested Gram-positive, Gram-negative bacteria and fungus.


Keywords


pyrido[3,4-d]pyridazine derivatives; pyrido[3,4-d]pyridazin-4(3H)-one; pyrido[3,4-d]pyridazin-1(2H)-one; antimycobacterial activity

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DOI: http://dx.doi.org/10.17344/acsi.2018.4590

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