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Synthesis, Anti-inflammatory and Antioxidant Activities of Novel 3H-Thiazolo[4,5-b]pyridines

Taras I. Chaban, Volodymyr V. Ogurtsov, Vasyl S. Matiychuk, Ihor G. Chaban, Inna L. Demchuk, Ihor A. Nektegayev

Abstract


5-Hydroxy-7-methyl-3H-thiazolo[4,5-b]pyridin-2-one was obtained by the reaction of 4-iminothiazolidin-2-one with acetoacetic ester. Further structural modifications include the introduction of diversity at the C5 and C6 positions. The anti-inflammatory action of novel thiazolo[4,5-b]pyridine-2-one derivatives was evaluated in vivo employing the carrageenan-induced rat paw edema method. The antioxidant activity of the synthesized compounds was evaluated in vitro by the method of scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals.

Keywords


thiazolo[4,5-b]pyridines; synthesis; anti-inflammatory activity; antioxidant activity

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DOI: http://dx.doi.org/10.17344/acsi.2018.4570

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