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Fused 1,5-benzothiazepines from o-aminothiophenol and its derivatives as versatile synthons

Batchu Chandra Sekhar


This review describes the reactions of o-aminothiophenol and its derivatives as building blocks for the synthesis of polyfunctionalised 1,5-benzothiazipines with pharmacological interest. Annelated 1,5-benzothiazipines were prepared by a cyclocondensation reaction of o-aminothiophenol and its derivatives with carbonyl and other functionalities. In case of carbonyl function this reaction takes place by a nucleophilic addition, followed by cyclisation concomitant with elimination of water. The objective of this survey is to provide a comprehensive account of the synthesis of various 1,5-benzothiazepines derivatives and their potential to develop better chemotherapeutic agents.


o-aminothiophenol; chalcones; cyclocondensation; green synthesis; 1,3-dipolar cycloadditions

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