Cover Image

Chlorocarbonylsulfenyl chloride cyclizations towards piperidin-3-yl-oxathiazol-2-ones as potential covalent inhibitors of threonine proteases

Ales Obreza, Katarina Grabrijan, Selmir Kadić, Fernando Juan de Lera Garrido, Izidor Sosič, Stanislav Gobec, Marko Jukič

Abstract


Using rescaffolding approach, we designed piperidine compounds decorated with an electrophilic oxathiazol-2-one moiety that is known to confer selectivity towards threonine proteases. Our efforts to prepare products according to the published procedures were not successful. Furthermore we identified major side products containing nitrile functional group, resulting from carboxamide dehydration.  We systematically optimized reaction conditions towards our desired products to identify heating of carboxamides with chlorocarbonylsulfenyl chloride and sodium carbonate as base in dioxane at 100 °C. Our efforts culminated in the preparation of a small series of piperidin-3-yl-oxathiazol-2-ones that are suitable for further biological evaluation.


Keywords


cyclization; amide dehydration; oxathiazole-2-one; threonine protease; covalent inhibitors; irreversible inhibition

Full Text:

PDF


DOI: http://dx.doi.org/10.17344/acsi.2017.3883

Refbacks

  • There are currently no refbacks.


Copyright (c) 2017 Ales Obreza, Katarina Grabrijan, Selmir Kadić, Fernando Juan de Lera Garrido, Izidor Sosič, Stanislav Gobec, Marko Jukič

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.