Synthesis and Biological Evaluation of Some Novel 1,8-Naphthyridine Derivatives

Sraa Abu-Melha

Abstract


A series of substituted 1,8-naphthyridine derivatives was synthesized to be used as cytotoxic and antioxidant agents by applying 1,4-dihydro-4-oxo-1,8-naphthyridine-3-carbohydrazide (1) as the starting material. Compound 1 was reacted with different reagents to afford the corresponding 3-heterarylcarbonyl-1,8-naphthyridine derivatives 319 which were tested for their in vitro cytotoxicity against Ehrlich Ascites Carcinoma, and antioxidant activity. Compound 15 showed the best cytotoxicity and antioxidant activity.


Keywords


1,8-Naphthyridine; Quinazolone; Pyrazole; Cytotoxicity; Antioxidant

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DOI: http://dx.doi.org/10.17344/acsi.2017.3617

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