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Synthesis and antiproliferative activity of 4H-chromonephenylhydrazones, 1H-pyrazolecarboxylates and pyrazolylmethanones

China Raju Bhimapaka, Nageswara Rao Rayala, Rajkumar Kommera, Dayakar Cherupally, Ramalinga Murthy Thampunuri, V Kalivendi Shasi

Abstract


Series of 4H-chromone-based hydrazones 3az, pyrazolecarboxylates 5ax and pyrazolylmethanones 6au were prepared and screened for their anti-proliferative activity on A549, HeLa, DU145 and MDAMB 231 cell lines. The hydrazone compound 3s with a chloro substituent on the chromanone moiety and a methoxy group on the phenyl ring displayed promising activity on A549, HeLa and DU145 cell lines. The compound 5p with a bromo substituent on the chromanone moiety and a methyl group on the phenyl ring displayed potent activity on DU145. Furopyrazolecarboxylate 5w having a methyl substituent on the phenyl ring displayed potent activity on HeLa cell line. The pyrazolylmethanone 6e with a fluoro substituent on the phenyl ring and compound 6j having a methyl substituent on the chromanone moiety and a methoxy group on the phenyl ring have shown promising anti-proliferative activity on HeLa cell line.


Keywords


3-Formylchromones; 1H-pyrazolecarboxylates; 1H-pyrazolylmethanones; cycloaddition and antiproliferative activity

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DOI: http://dx.doi.org/10.17344/acsi.2017.3453

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