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New Bioactive Heteroleptic Copper(II) Carboxylates: Structure, Enzymatic and DNA-Binding Studies

Afifa Mushtaq, Saqib Ali, Muhammad Nawaz Tahir, Hammad Ismail, Bushra Mirza, Muhammad Saadiq, Muhammad Abdul Haleem, Muhammad Iqbal

Abstract


Two new binuclear O-bridged copper(II) carboxylates with chemical formulas [Cu2(3-ClC6H4CH2COO)4(phen)2] (1) and [Cu2(3-ClC6H4CH2COO)4(bipy)2] (2) where phen = 1,10-phenanthroline and bipy = 2,2′-bipyridine have been synthesized and characterized by FT-IR, UV-Visible spectroscopy, CHN analysis and single crystal XRD. The results revealed distorted square pyramidal geometry around each copper atom of 1 and 2. The DNA interaction studies showed strong binding with Kb = 5.07×103 and 4.62×103 M–1 for 1 and 2, respectively. Both complexes showed strong enzyme inhibition, i.e., 70 % and 90 % for α-glucosidase with IC50 = 34.6 and 30.1 µM for 1 and 2, respectively, where acarbose was employed as control. However, both the complexes were found inactive against α-amylase. Using galantamine hydrobromide as control, 1 showed moderate inhibition activity (47 %) with IC50 = 179.4 µM for acetylcholine esterase whereas 2 showed strong inhibition activity (76 %) with IC50 = 95.8 µM for butyrylcholine esterase. The data reflects active anti-diabetic and anti-Alzheimer’s nature of the synthesized complexes.


Keywords


Copper(II) Carboxylates; Structure; Enzymatic study; DNA-Binding Study

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DOI: http://dx.doi.org/10.17344/acsi.2017.3250

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Copyright (c) 2017 Afifa Mushtaq, Saqib Ali, Muhammad Nawaz Tahir, Hammad Ismail, Bushra Mirza, Muhammad Saadiq, Muhammad Abdul Haleem, Muhammad Iqbal

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