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Fe3O4@SiO2-NH2 nanocomposite as a robust and effective catalyst for the one-pot synthesis of polysubstituted dihydropyridines

Mohammad Ali Ghasemzadeh, Mohammad Hossein Abdollahi-Basir

Abstract


A practical, simple, and efficient method for the synthesis of polysubstituted dihydropyridines was described via multi-component reactions of aldehydes, arylamines, dimethyl acetylenedicarboxylate and  malononitrile/ethylacetoacetate in the presence of Fe3O4@SiO2-NH2 nanocomposites. The present methodology provides a novel and efficient method for the synthesis of dihydropyridine derivatives with some advantageous such as excellent yields, short reaction times, recoverability and low catalyst loading. The nanomagnetic catalyst could be readily recovered using an external magnet and reused several times without any significant loss in activity. The catalyst was fully characterized by FT-IR, SEM, XRD, EDX and VSM analysis.


Keywords


Fe3O4@SiO2-NH2; magnetite; multi-component reaction; nanocatalyst; dihydropyridine.

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DOI: http://dx.doi.org/10.17344/acsi.2016.2386

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Copyright (c) 2016 Mohammad Ali Ghasemzadeh, Mohammad Hossein Abdollahi-Basir

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