Cover Image

Heteroannelation of cyclic ketones: Synthesis, characterization and antitumor evaluation of some condensed azine derivatives

Essam A. Soylem, Mohammed G. Assy, Ghania M Morsi

Abstract


A series of pyrimidine and thiazine derivatives synthesized by one pot reaction of cyclopentanone with a mixture of an aromatic aldehyde namely o-anisaldehyde and different ureas namely urea, guanidine and thiourea, respectively. Furthermore, cycloaddition reaction of active methylene reagents namely acetyl acetone, malononitrile, ethyl cyanoacetate, cyanoacetamide and N-phenyl cyanoacetamide with 2,6-bis(2-methoxybenzylidene)-cyclohexanone afforded chromene and quinoline derivatives in basic medium.  The antitumor evaluation of some new compounds against three human cell lines namely MCF-7, NCI-H460 and SF-268 showed significant and moderate activity compared with the positive control doxorubicin.


Keywords


Cyclopentapyrimidine; Thiazolopyrimidine; Quinazoline; Chromene; Antitumor activity

Full Text:

PDF Untitled


DOI: http://dx.doi.org/10.17344/acsi.2016.2297

Refbacks

  • There are currently no refbacks.


Copyright (c) 2016 Essam A. Soylem, Mohammed G. Assy, Ghania M Morsi

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.