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A Rapid One-pot Synthesis of Pyrido[2,3-d]pyrimidine Derivatives Using Brřnsted-acidic

Roghayeh Hossein Nia, Manouchehr Mamaghani, Khalil Tabatabaeian, Farhad Shirini, Mehdi Rassa


Pyrido[2,3-d]pyrimidine derivatives were synthesized regioselectivly in good to high yields by one-pot three-component condensation of 6-amino-2-(methylthio)pyrimidin-4(3H)-one, aromatic aldehydes and ethylcyanoacetate or meldrum’s acid using 1,2–dimethyl-N-butanesulfonic acid imidazolium hydrogen sulfate ([DMBSI]HSO4) Brřnsted-acidic ionic liquid as catalyst. Solvent-free mild reaction conditions, short reaction times, easy work-up, and reusability of the catalyst are the main advantages of this protocol.


6-amino-2-(methylthio)pyrimidin-4(3H)-one, ethylcyanoacetate, meldrum’s acid, pyrido[2,3-d]pyrimidine, ionic liquid, one-pot three-component reaction.

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