Cover Image

Synthesis and Biological Activity of New Diazenedicarboxamides as Potential Anticancer Agents

Jure Vajs, Sanja Soviček, Petra Kureljak, Nikolina Stojanović, Ivana Steiner, Domagoj Eljuga, Damijana Urankar, Marijan Kočevar, Janez Košmrlj, Slovenko Polanc, Maja Osmak

Abstract


To increase the effectiveness of cancer treatment, more effective anti-cancer drugs, as well as the new improved strategies of cancer treatment, are urgently needed. Our previous results have shown that various diazenes are cytotoxic to different tumor cells and can even revert the resistance to cisplatin and vincristine. We also demonstrated that unsymmetrical diazenedicarboxamides 1 and 2 exhibited promising cytotoxicity. The aim of the present study was to synthesize new diazenedicarboxamides with acceptable solubility and good cytotoxicity. Here we report the synthesis and biological evaluation of new N,N’-disubstituted diazenedicarboxamides. We found that a modification of either 1 or 2 led to the more active compounds. The most effective among them was diazenedicarboxamide 11, which can be considered as a new potential anticancer agent for the tumors of different origin, as well as for the drug resistant tumors.


Keywords


Diazenedicarboxamides, tumor cells, anticancer drugs

Full Text:

PDF

Refbacks

  • There are currently no refbacks.


Copyright (c) 2013 Jure Vajs, Sanja Soviček, Petra Kureljak, Nikolina Stojanović, Ivana Steiner, Domagoj Eljuga, Damijana Urankar, Marijan Kočevar, Janez Košmrlj, Slovenko Polanc, Maja Osmak

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.