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Synthesis, Characterization and ِAntimicrobial Activities of Some New Heterocyclic Schiff Bases Derived from Thiocarbohydrazide

Kamelia El-mahdy, Azza El-Kazak, Mohamed Abdel-Megid, Magdy Seada, Osama Farouk

Abstract


 The reaction of prazolobenzothienopyrimidine-3-carbaldehyde 1 with thiocarbohydrazide afforded the Schiff’s base 3. The latter compound reacted with some electrophilic reagents to give 1,2,4-triazoles 4–6 and 1,2,4-triazines 79. Treatment of compound 3 with 2-cyano-3,3-bis(methylthio)acrylonitrile gave the corresponding 5-amino-4-cyano-3-methylthiopyrazole derivative 11. The reaction of pyrazole 11 with carbon disulfide afforded dithioxopyrazolopyrimidine 12. Acylation of compound 11 by using acetic anhydride yielded acetamide 13. On the other hand, the cyclocondensation of pyrazole 11 with acetic anhydride in pyridine yielded pyrazolopyrimidine derivative 14. The reactivity of compound 11 towards formamide and phenylisothiocyanate to give the pyrazolopyrimidines 15 and 16 was studied. The newly synthesized compounds were screened for their antimicrobial activity.

 

 


Keywords


Schiff bases; triazines, triazoles; carbothiohydrazide; Antimicrobial activity

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DOI: http://dx.doi.org/10.17344/acsi.2015.1555

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Copyright (c) 2016 Kamelia El-mahdy, Azza El-Kazak, Mohamed Abdel-Megid, Magdy Seada, Osama Farouk

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