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An axial chirality and disorder of positional isomers in a crystal of highly cytotoxic 3-acetyl-1,3-bis(2-chloro-4-nitrophenyl)-1E-triazene

Krešimir Molčanov, Slovenko Polanc, Maja Osmak, Biserka Kojić-Prodić

Abstract


Biologically active 4-nitro-substituted 1,3-diaryltriazene, a chemical analogue of 1,3-bis(4'-amidinophenyl)-triazene-berenil®, belongs to the novel, chemically modified class of potent antitumor agents. Its structural characterization by X-ray analysis and 1H NMR spectroscopy is performed to determine molecular overall conformation in view of its possible interaction to DNA   

Keywords


axial chirality; enantiomeric disorder; molecular structure; crystal structure

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DOI: http://dx.doi.org/10.17344/acsi.2015.1420

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Copyright (c) 2015 Krešimir Molčanov, Slovenko Polanc, Maja Osmak, Biserka Kojić-Prodić

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